I have also been on medication for years. I will probably need them throughout my life, but that's OK. I have been on several different antidepressants and some worked and some didn't. My psychiatrist is very knowledgeable and keeps up with the new research. He spent 2 years finding the right mix for me and I am doing much better. I didn't do well on only one medicine. It took a combination to work well.
I think it's critical to find someone who is genuinely passionate about their work because there are new discoveries all the time. People here also advocate for therapy so why not give that a try as well.
Like Genetic says---why suffer? Even if you can get only some relief that's a big help.
Please don't give up. You may need to do some research on new medications yourself and tactfully suggest them to your dr. Also read the Resources thread at the top of the forum.
Good luck to you and welcome to our group. I look forward to reading your entries and learning what you find.