Nearly 40 years of trial and error (mostly error) with dozens of antidepressants, and this year it finally became clear that they just don't work for me... beyond what is well known as a placebo effect, that is. You may have a 'drug resistant' depression, but please don't waste more time with meds when there are alternative treatments available. Talk to your counselor or doctor about rTMS - Repetitive Transcranial Magnetic Stimulation. It is fairly new and shows good results for some of us who don't respond to meds. I am trying to get rTMS but it is not yet covered by my insurance. Anyway, good luck and definitely consider moving away from meds... IMHO they can be good but are definitely NOT for everyone. My last med (Viibryd) seemed to work awhile, then fizzled as they often do, BUT they don't tell you that some people have a hellish time going off such a med. I did a fairly quick taper off of the stuff (3 weeks, just like the initial ramp up timing) but am having extremely nasty mood swings and other residual withdrawal effects, even months after stopping the drug. If you go with another drug, be VERY aware of all the risks and the fact that the makers usually don't even KNOW how they work, let alone how an individual person might be negatively affected. I am no spring chicken with these meds and this one feels like it may have caused long-term or even permanent damage. Time will tell when Big Pharma might finally have to own up to it's ways.