I'll tell you what has been the best thing that happened to me in regard to depression.

I read that 70% of depressed people cannot metabolize vitamin B9 (folic acid) which
the brain needs create the "good feeling neurotransmitter" serotonin. There are
several enzymes missing in the stomachs of folks who cannot metabolize folic acid
that will cross the blood-brain barrier and be effective for treating depression.

There is a relatively new food med call Deplin, which is a concentrated form of folate
that can cross the blood-brain barrier and builds serotonin nicely in the brain of
those missing the enzymes necessary for the brain to use folate.

Usually, a genetic test is needed to determine if we need to take Deplin, but my
psychiatrist thought that if we tried it and it worked, there'd be no need to have
genetic testing done. I take one tablet a day (20 mg.); it's about $15. per month
for a prescription where I live, and I wouldn't be without it, honestly.

It begins to work after about two weeks. It's not a cure-all, but if we get our
diets straightened out (and I mean by reducing sugar drastically and cutting way
back on grains, substituting nuts, seeds, and green vegetables) it makes the Deplin
that much more effective.

I don't notice any side effects, but I can tell when I add sugar to my diet or eat
grains that my feeling tone will drop for 24 hours. (That may just be a personal
sensitivity of mine, so you might not need to change your diet in any way.)

It just works for me. I'd ask about it if you tend to be medication resistant.