I had been dealing with a trauma which caused the anorexia I had to be hospitalized for....my pdoc put me on seroquel because of the nightmared caused by the trauma.....a really high dose which completely knocked me out for most of the day.....I didn't gain anything for about a year, then I just got up to a safe weight.....seroquel had no effect on my weight even though my pdoc hoped it would on top of handling the PTSD.