Hello. I am new on this site. I struggle constantly with depression and have stayed on meds since 1989. I am now in my mid-50s, female, dealing with menopausal hormonal issues, and taking generic fluoxetine. It has never worked as well for me as brand-name Prozac did, but I have not been able to get brand-name Prozac since the generics went on the market. Now, even the best of the generics has stopped working for me. Also, my doctor stopped taking my insurance, and I am having to wait about a month before I can get an appointment with a new doctor who takes my insurance. Meanwhile, I wake up every morning at 3:00 and can't go back to sleep. I just lie there, unable to sleep, and unable to turn off horrible thoughts. I cry a lot, and sometimes I'm crabby to my husband for no good reason. I am posting here in hopes of getting encouragement from those who have been though something similar. Thank you and best wishes to everybody.