When I was first diagnosed, Lamotrigine is what I was first put on. I remember that it worked some, but I had horrible headaches. But about 2 weeks in, my best friend told me that we were hanging out more then than before because I was less of a b!tch (meaning I was less irritable). Unfortunately, when I got to about 100mg, I got a rash. It wasn't THE RASH, but it covered most of my body and was completely unbearable so I was taken off it per my request. Pdoc thought I should give it more of a chance, but I said no way! But the good part of the story is that it DID take effect quickly in me. I will say that, and if the rash hadn't been so bad (the headaches went away after a week or so), I would have held out to see its full effects...but I was scratching all day every day and couldn't take it.