None that I am aware of, but that is because they are just supplements. If they really reduced cortisol they would be controlled by the FDA and be a script only. Cortisol is a natural steroid, like cortisone etc... It is very important for many functions, including keeping inflammation under control so we live, as well as many other functions. Cortisol can be elevated with chronic stress, PTSD, Depression, but that is not necessarily always the case. SSRI's are the only medications shown to reduce hypercortisolemia, but why they do that is very complex.

FYI, if these supplements claimed to treat fatness they would get in trouble, but they can claim to lower or raise anything without proof as per FDA guidelines.

Dr.S