I find it helps me to remind myself that I believe there is probably no particular point in life. For me, thinking of it as it is here and we are alive so what can I do to make it not unendurable - makes it easier. The same is true with lack of significance. To me, the truth in the bigger picture, is that my existence is no big deal one way or the other. But I do have friends who appear to like me and find me not unuseful, pets who depend upon me, and a family with some members who might claim not to dislike me and our interactions are not always unpleasant.