Yes, pdocs are a major pain in the arse! There may be a few good ones out there, but I've had more bad ones than good.

Obviously it's your pdoc you need to talk to about this, but until you do, I was wondering if he had suggested upping the Seroquel or did you do that on your own? The reason I ask is Seroquel in that large of a dose will knock most people on their butt. I took that much at the height of severe mania and I think I did sleep but the effect was very scary.

From what you say it sounds like your dealing with severe depression and Seroquel is an anti-psychotic. I guess they're using it now in conjunction with other meds for depression. At that high of a dose it will probably make you very tired and maybe more depressed.

I'm just giving opinion and I could be way off. Not trying to give medical advice. Just want to be helpful if I can. I hope you get ahold of your pdoc soon, and I'm sorry you're having such a hard time. Take care.