I took Lyrica for a short time for help with my ms pain, it helped somewhat almost immediately, I don't believe this drug has to work itself into your system. Why? Well within two weeks I was taken off because I retained water to a point that was ridiculous.... too bad because it helped some of the pain I experience... Please talk with your doctor... It could be the drug or could be that you did too much try a day or two taking it easy with the drug and see how you feel... maybe it was helping and that is why you overdid... so easy I know.. after 18 years I still can't pace myself on a good day....gentle hugs to you Linda