Cymbalta affects SSRI and norepinephrine. The SSRI part would be similar but to equal to Prozac, Paxil, Zoloft, etc. Keep in mind that none of these drugs are the same.. each affects different people differently. The norepinephrine part is the pain part. Cymbalta is used both as an antidepressant and a pain-management drug.

I am on Cymbalta for both depression/ptsd and chronic pain. I can honestly tell you that it is working well for me.