I loved what Zyprexa did to bring me down off a manic episode and maintain my sanity, but it put about 25 lbs. on me in a matter of weeks and made my blood sugars go completely ape-****. (I was diabetic before I went on Z, so it wasn't unusual for me to have high sugars, but they went totally out of control when I was on it.) So I had to come off of it.....a few months later it became apparent that I don't do well off antipsychotics, and I was put on another one.