What i found was taking AD's definitely propped be up and put me in a space where i was better able to cope with the issues behind my depression. while the underlying issues must be fixed, AD's can help u get out of a runt...seriously, why do things the hard way? the physiological side of depression is that is caused by a chemical imbalancein ur brain, and fo me, it did stuff such as improve my concentration and ease the obsessive urges i was having to harm myself.