I've been on Seroquel for 4 months now and was in it for over a year in the past. The only side effect that I get is it makes me feel drunk. So I have to allow for 12 hours of no driving. The only other thing is a lot of people complain of weight gain but I've been actively losing weight (with weight watchers) so it doesn't seem to affect me now. Even with these side effects. I love it. It does what I need and the minor life style changes have been a good thing anyway. Good luck!