I started on wellbutrin on Saturday and immediately lost my appetite. Now I remember why I wanted to get off it the last time. Now I was happy about it when I needed to lose weight but now I am at my target weight and I want to stay at this weight. However my Dr. said it is a very good drug. My mood is the same, I am still hopeless, crying, isolating myself, but I have no desire to eat. I had two pieces of toast today and I had to force that down. I don't want to start looking sickly. Has anyone else had this problem or any other problems with Wellbutrin?