I don't do well on meds... actually, I do WORSE on meds than when I am off. I have tried just about ever med available for depression, anxiety, mood swings, and PTSD over the last 7 years. I'm no longer willing to try anything outside of PRN (as needed) meds for sleep and anxiety because it always makes me more suicidal and more impulsive. My cycles are less severe when I am not on meds.
I have not found anything that works yet, but I am hoping tackling some of the underlying issues with trauma-specific therapy will help. It was the only thing that helped a bit in the past, but I did not continue it because of insurance issues. I'm hoping to be able to get back to that work because I feel it's what drives everything else.
Can you pinpoint what of the therapy helps? Maybe increasing that could work where the meds have failed? I'm not one to buy into the theory that "you just have to find the right meds"... sometimes meds are not right no matter what, it's an individual thing.
((hugs)) sorry it's rough right now.