It's not fair at all right now to fall in a Mania Panic. Mania is a possibility to keep an open mind about but all those symptoms also very very easily, perhaps more easily, fit under depression and anxiety. Irritability, problems concentrating ... easily could have been the depression symptoms breaking through. (you already said he couldn't concentrate before the meds)

It's also not fair to jump on blaming the meds either. Like I said, they could be a relapse -- the drugs could have never been effective in the first place. They may have dulled or numbed him a way that makes him a different type of depressed than he was before, but the negative symptoms he is experiencing could be the remnants of depression.

Of course, the meds still could be making the depression worse by adding irritability or modifying other symptoms. There are other treatment options worth exploring.

Just don't get ahead of yourself when it comes to the possible bipolar. Often MI and stress take a long long time to resolve and your support and desire to learn mean a ton. Please keep looking for more information and have faith that your husband will heal.