The personality change did not happen before the meds, he was only experiencing OCD and anxiety. He was completely himself while at home. You didn't read my original post right. From March 2011-February 2013 he was traveling. Home on the weekends. The end of February was the start of the Zoloft. He ended up finding something closer to home in May, was home every night thereafter. The complete personality change started to happen near the beginning of June. Someone who is not depressed would definitely have a reverse reaction to this medication IF it was not needed. He has no family history of depression, bipolar disease, or any other mental/social anxiety disorders. This was brought on by beig away from home for a long period of time, alone, and sleeping in different hotels for 2 years. Before entering into that career, he NEVER had any signs of OCD, Depression, or any of the problems/symptoms from traveling. This happens to people in the army, people who relocate for jobs, etc. They usually have no prior history. I'm just trying to get across that this man was completely "normal" before the traveling/getting on the Zoloft. My frustration is leaking out, I apologize if it sounds that way.