I can very much relate to prior comments Years ago when I was on Zoloft I experienced the "light switched on suddenly" event and I felt reborn. It was unbelievable. It lasted 4 or 5 years, then I had a life changing event call retirement and have fallen into unprecedented depression and anxiety now and am using both Lexapro and Wellbutrin and waiting for some results. The daily wear and tear of continued depression and anxiety are exhausting.