I always thought that I could be just fine without meds, until this last 2 weeks. Topamax pooped out, then the Wellbutrin pooped out. My moods have been all over the place, depression slammed right back in. I've been a mess. Cognitively I am not able to function. I can hold it together and put on a face and make it not show I'm having a problem, but inside I'm a mess. I'm going to the outpatient clinic tomorrow hoping to see my doctor. I really don't want to do it, but the only real antidepressant that has ever helped me was Paxil, but it totally killed Mr. Happy. I'm 30 and that's not cool. Haven't tried Lexapro, Zoloft or Effexor. Only on Celexa for a few weeks a few years ago. So I dunno. Sorry for my rant. Yes at this point in my life I am totally dependent on my meds.