when i was on effexorxr, i lost 38 lbs. i only ate every two or three days. my doctor wouldn't help me come down off and my pharmacist helped me. taper very slowly. the withdrawal is horrible. don't go down more than 37.5 mgs and get used to that before you reduce more. it took me a long time and i wasn't on as high a dosage as you are. my head felt like it was full of tumbling rocks, i had electrical zaps and nausea. if you'll committ to slowly coming off, you'll be fine. just don't rush it...........xoxoxo pat ps. keep me updated.