I've been on 20 mg of Abilify for about 4 years now. When I feel a mania coming on I increase it to 25 mg for one week (as prescribed by my doc) to counteract the mania & it works. Helped with delusional thinking & irrational thoughts that led to irrational behaviors. (Though I have had one relapse while on it & had to add Wellbutrin one winter when the depression hit, but I went off it in the spring). I also take Lamictal, Concerta, Provigil, Trazadone, & Klonopin. The combo has worked for me, but I DID gain 50 lbs. since being on the Abilify & I'm trying to address that now. Don't want to get off the Abilify--it works too well for me. Hope it will work for you. I know A LOT of people on it (& unfortunately, a lot who have gained weight, too). Good luck.--Suzy