You have gone above and beyond the call of a friend. You've been wonderful to her and if she doesn't see that now, she will see it later down the road when she improves. Don't take it to heart if she's a little put off. YOU have been a godsend to her. Absolutely, sit her down for a little talk and start by saying how you understand how hard things have been for her and that you were happy to take her in, drive her to her doctors appointments and be there for her (remind her a little of all that you've done she may need that). Tell her, unfortunately, YOU are having a hard time now keeping up with things and though you don't like to ask her to leave, you really must at this point. Tell her it is too much for you now with school starting for the boys and taking care of their needs. Ask her if there are any other friends or family members that she can stay with until she gets on her feet? If she still has nowhere to go, doesn't the "Y" still help people with no housing? Tell her you'll drive her there and hope to stay in touch as you really care about her. I think you'll do fine. You've been a great friend. Don't feel you haven't done all that any human being can do for her.