The short answer is yes. You will probably have to make some pretty radical changes in your diet and nutrition. I am using Joel Fuhrman's "Eat to Live." I started it after I had to have a stent put into my heart. I am on Seroquel, one of the kings of weight gain. I have actually lost 13 lbs. since I started the diet. It takes a lot of self-control, but if weight gain really bothers you, it's worth a try.