It hasn't really been studied for later in life ladies, just puberty and childbirth hormonal onsets, as far as I've been able to tell. But it would make sense to show up at this time too. BUT ya never know. Drs don't know for sure where it comes from, what causes it so it could be something we ate for all we know. I"m teasing, I know its got genetic markers and physical properties in the brain. I also had some difficult family issues going on at the same time too, my first trip to find help for depression and anxiety was two years before my manic episode occurred.