I was already overweight when I first started taking meds. I had lithium toxicity which affected my thyroid and resulted in a hospital stay for psychosis. They stopped the lithium but kept me on seroquel, prozac, and klonopin. Thyroid testing is done 4 times a year. My weight went up, up, up. This was over a few years. Then it stopped. And over the next 18 months I lost 70 pounds. The only Med changes were the seroquel fluctuating between 600-800 mg. Then in February I had another psychotic episode brought on from high doses of steroids and being on prozac for over ten years. I spent 3 weeks in the hospital while they stopped the steriods and prozac and started me on depaoke. I think the depaoke works but the weight gain is back. 35 pounds already. I was so happy to have lost the 70 pounds and now I'm disgusted with myself. My pdoc said she could lower my seroquel but I refuse. I need it to sleep. Part of me just wants to stop the depaoke but I'm afraid. My next appointment is next week and I'm gonna see if she thinks another Med may be a better fit.