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psisci said:
Yes it is very likely serotonin related, but it is definitely not seizure activity. My guess is that it is a peripheral nervous system, thus norepinephrine mediated down or up regulation of the long nerve fibers in the PNS. Why serotonin drugs like paxil do it, but others do not is unknown.

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Which would make complete sense since Effexor is an SNRI , in that it inhibits norepenephrine(sp) reuptake as well.

Thank you for your insight. Its become a curiosity as well to me and any info I find is helpful.