I've been on 20mg of Latuda since 8/8. I have not gained weight. I take it at bedtime with 50mg of Seroquel. I have noticed improved mood and I'm very pleased with how "even" I feel. I noticed a difference in mood about 7-10 days after I began taking it. I have experienced some big losses and changes recently and I feel relatively "stable" outside of normal sadness and other feelings--typically I would have experienced a hypo episode at a minimum.