I take saphris, an antipsychotic, it is a cousin to zyprexa but dissolves under the tongue so bypasses the stomach route, I have not gained weight on it and it has been very helpful for me, this is only my experience with it, obviously everyone is different and will react to meds differently. Originally my dr had hoped to only have me on saphris and effexor but my generalized and social anxiety disorder has amplified my bp. I take several other meds too, mood stabilizers for mood and weight, antidepressants for gad and add, and anti anxiety med for gad. My dr did a dna test which the results are in her computer so all my meds are cross-referenced as to how they react together, so far I've had good results.