im in the same boat. i take 100mg of zoloft a day & in the past month some days ive taken more. so i have some cymbalta left from when i was on it & i was wondering if i could take it until my zoloft refill. i know cymbalta affects norepinephrine along with serotonin but zoloft only affects serotonin. next time im gonna try & get my zoloft raised. i wish u the best on your meds. i know how u feel. right now im relying on my Pdoc to give me samples of abilify & straterra cuz of financial probs. hard to afford anything that does not come in generic. it seems like my doc is more cooperative when my hubby is in there with me.