I've never been able to take allergy meds, etc. with a decongestant in them because I find it makes it impossible to sleep. I've learned to pick out the meds without the decongestant and I do much better. I'm not sure it is particularly a bipolar thing. I think some people are just sensitive to whatever the ingredient is that works as the decongestant. I know people who aren't in the least bipolar who have the same issue.