Been on lithium for 10 years (low dose last 7 yrs). Also lamictal 10 yrs. Neither done anything for me. Dr told me that therapeutic and toxic level for lithium are very close to one another so it's hard to dial in a dose which gives you relief. I hit therapeutic dose once (1800 mg) and felt very relaxed, focused, no irritability, etc. then immediately had problems with my muscles working. Recently tegretol helped stabilize my moods/concentration but had to stop due to side effects. Had side effects with depakote, too.