This is a complicated question. And I think part of the complication is that the term "depression" is used to define what may actually be more than one condition. We probably just don't know enough yet about the causes of depression to tease out exactly what's going on with one person vs. another. The causes of the depression and the relative contributions of psychosocial factors and biology may vary from person to person. I've known people who were depressed (or bipolar) despite perfectly reasonable childhoods and good life circumstances. I've known others whose depression seemed more related to difficult things going on in their lives. I've known people who have done fine after a year on ADs and subsequent tapering, and others who seem to need to stay on meds.

I really think the only way to find out what will happen is to decide with your doctor when to attempt to come off, do so carefully and with supervision, and see how it goes.