I don't know, reading your original post and some of your replies/clarifications I get that you're "dissatisfied" with your life. But it seems you're casting about (moving, divorcing, relationship with your sister-in-law, living alone, "starting over," etc.) outside yourself rather than getting a solid read on what is "really" wrong. I'd ask your wife to try a marriage counselor and make sure your marriage is beyond hope and I'd maybe even do a little individual counselling or looking at your own hopes/dreams/situation to see if you can't get a clear "goal" that will do one thing well (and the rest will follow) whether it is a career, marriage, location, or personal goal. You see to me to be trying to go in too many directions at once and thus spinning your wheels. Get off the ice by checking your heart for what you really want and going after that. It's your life and other people can't really make us happy/unhappy, they're "out there" and if you are okay within yourself your world should fall in place easier.