Sorry you are having such a battle with depression. I'm fighting the same battle and have had medicine stop working. So I sympatize with you.

Depression is hard for family members to deal with. They don't know what to say or what to do because nothing works. They get furstrated and feel at a loss of what to do.

I'm glad you are seeing a therapist. Have you tried taking your wife in for some marital counseling? Might make her understand it more.

Hopefully, whatever meds the doctor puts you on will work for you. Good luck.