I take Seroquel both regularly and PRN. I take 150 mg at night and 100 mg in the morning and when I start to go into a hypo/manic episode, I up it until I start getting better. Then slowly lower it again, by 50 mg/week, until I (hopefully) get back down to my baseline dose.
For me, the regular dose has helped to prevent both hypomania and mania (though I've had two breakthrough manic episodes), the evening dose helps enormously for sleep, and the PRN is effective in bringing me down, though it tends to help me sleep again a while before it helps with the rest.
So, overall, for Bipolar, it's been effective for me.
BUT: I crave sweets all the time and have gained a lot of weight, if I don't get enough sleep I fall dead asleep at work, anywhere really... At first it slowed down my thinking, but these days I don't think it's as much of a problem. It's also ended up helping me a good deal with my anxiety, and this is one of the reasons that, despite the side effects, I have stayed with it. My pdoc has suggested Abilify on a couple of occasions (due to complaints re side effects), but he's said that it probably won't help me with anxiety so much...
Maybe you could do a trial run of taking it every day -maybe starting with a low dose (the first 50 mg I told initially practically put me in a coma, now, of course, I'm far more used to it). See how you do, if it helps, give it some time... These things are so different for everyone, you don't really know until you try.
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