I've been taking Cymbalta for some time now. I started on the 30 mg and then moved up to 60. It took probably three months for me to really get the full effect of it. It's the only antidepressant to work for me, and I take it in combination with Topamax.
A couple of years ago I went into a really bad slide for over year--a very deep depression and we tried all kinds of other meds separately & in combination with Cymbalta. I had very bad side effects with them, & my pdoc finally up'd the Cymbalta to 90 mg. That's sovedl the problem and I've been at that dosage ever since. It's done a great job for me but I do need to take it in combination with a mood stabilizer.