Feeling disconnected from everyone is very common with someone who experiences depression. Right now, she is probably feeling so scared of losing everyone in her life, and that might be why she could be baking off a little bit, as to protect herself. What she needs most is to know that she is not alone ... let her know that you are there for her no matter what, but you also have to respect her if she needs some time to herself. Right now she is needing you, so all you can really do is be there for her, and make sure that she knows it.
Best of luck
Jacq