Mine know and are very supportive. I have 'reasonable accommodations' because the nature of my illness comes under the disability discrimination act in the UK, and legally they have to take it into account. But it is more than just the legal thing, as they really do care.
I gave this to my managers (its from the Mind site, which is excellent by the way) and it helped them too.
http://www.mind.org.uk/Information/B...orkinglife.htm