I took Saphris for a few months at 5 mg which was plenty to take care of my symptoms. The only side effect was the sleepiness which is clearly warned about. I found I needed 8-9 hours of sleep each night and that was plenty to keep from feeling groggy the next day. Other than that no other side effects. I actually lost weight because for me it suppressed my appetite to the point that I had to remind myself to eat.