I have tried them all. My depression and anxiety is not in question or the issue here. I have the depression and anxiety under control for now any ways. I even have complete normal days. With no meds! The nice thing about Wellbutrin, I only take it when I feel bad and it kicks in. It's not like any of the zombie antidepressants out there. And .25 xanax as needed, again, days with none! I assure you I am prolly more functional then most here. I do need to address the adhd. And in case some where not aware, people can have depression, anxiety and adhd. It's very common to be on wellbutrin, adderall and xanax. This is not a unreasonable combo.