I am med resistant and had to stop all of them cold turkey due to a conflict with a blood thinner I start on. I was off all psych meds about 2 months. Needless to say, I had to go up or down. I went into a deep depression. They have now started adding my psych drugs back one at a time. I had just started Welbutrin when I had stop taking everything. They have just put me back on it and I'm now up to 300 mg. I haven't had any trouble with but can't really tell that is has helped any either. I don't notice any flatness at this point, not much good are reducing appetite that is caused by the Seroquel.