How long does menopause last? I am 57 and had my last period at 52. Anything can set me off. If I enter the wrong password and get a message that it's invalid I hit the ceiling! My mother was put on estrogen when she was in menopause and got breast cancer in her 80s so I don't want to chance that. I had a very difficult time with mood swings when I went through puberty at the age of 9. The first episode of depression that I remember was at the age of 4 when we moved from Alaska to Washington State. (later we moved back to Alaska). All my known relatives are dead so I am totally alone.