She should def ask her pdoc if she is taking them right! If I understand, she is taking the 4 times a day at once and her 2 times at once as well. My experience is spread them out as specified on the script for the best results. I too took all 400 mgs of Lamotrigine at night and I didn't get the results I wanted. So I tried doing it the way it was prescribed. It made me sleepy at first but it's not too bad now. Much better than the way I was feeling. Since I have divide them in half, 200 mgs in the morning and 200 mgs at night, usually around 7 to help me fall asleep, my moods and cycles lessened in severity and length of time. Hope this helps