I take them at night around 10pm and I am comatose until around 230pm the next day basically. I have skipped my saphris tonight and have yet to go to sleep (it is almost 3am) so I believe it is the increased saphris that is the problem, not the depakote. I see my ther in the morning but my pdoc is in the same bldg I may see if I can slip a note to her while I am there to ask about it. Though I see her on Wed morning too.