I have been on Zoloft for five years and it works wonders. The only drawback is that it is difficult to wean off. I take 200 mg a day with 150 mg of Effexor and 900 mg. of lithium for a bipolar diagnosis and the combination has kept me going strong for years. Zoloft is a good med except when you need to come off of it it is a stinker, but it can be done. Good Luck to You.