I've been on Deplin. Expensive. Was put on it when a test my doctor ran showed I had a genetic predisposition to depression. I belief Deplin is L-methylfolate (something that sort of helps depression). As much as I would have liked to believe it would help me, I don't think it worked at all. And it eventually got to the point I could no longer afford it. Therapy has helped more. I'm also on Celexa, but I'm not even sure that is what is making me feel better.

BTW: The Deplin cost me $180 for a 90 day supply and insurance will not, to my knowledge, cover it.

Good luck.