I have been on it for a couple months... 300mg of SR for past 3 weeks. Taking it for low level depression and lack of motivation in certain areas due to a lack of confidence and a poor self image lately (been unemployed for a while). Felt up and down on it... some days feeling pretty good, nothing great. But other days fairly depressed with bouts of near crying. Also, have had periods of agitation and anger where I felt a lack of control. Luckily, things seem to have finally leveled off with that the past few days. Still hoping for a big uplift in mood, but motivation is a little better and I'm feeling a tad more sociable. Otherwise, my libido has gone down to almost zero which I don't mind since I am single. But it doesn't help my motivation to get out and meet new people. Also, I have had increased urination and sometimes difficulty urinating. I still feel hungry but don't need much to feel full. It's weird but food just doesn't do as much for me as it used to... but I don't even seem to care. Slowly losing weight but am glad since my activity level has gone down a lot since summer. I know this is rambling... If I still don't feel anything major in a couple weeks, I may ask to add a low dose of zoloft or something. I guess I could go up to 450mg. Maybe I am just expecting too much?