Medication is so hard.....I have failed dozens. It hasn't been pretty at all. I have children that are bipolar as well. For all of us, Lithium doesn't do anything. But Seroquel has worked well. Possibly, the Depakote, which I have taken with no success should be changed. Not saying Seroquel is for all, but I was taking that along with Trileptal which are both for mood disorders. Of course, I take Wellbutrin, what would life be without an antidepressant? My doctor also tried me on Levoxyl, which is an underactive thyroid medication. New studies have shown a stiumlating thyroid medication can also stave off some of the bipolar symptoms as well. I take Klonopin as well as needed. Unfortunately it is needed more othen than I would like. I do want to tell you though, I am about to try to get pregnant so I have been tapered off all my meds but the Seroquel, and I am doing terrible. Point being the proper drug cocktail is hard to find, you must discuss with your doctor that it just doesn't work for you. Something different for everybody, my twins who are bipolar have slightly different meds because that is what worked for them. Don't wait!!! Trust me, I have and the results were not good. Hope this gives you a little insight as I live bipolar with 3 kids with it and me everyday and that is just the start. Please post how you do!!!!