This is precisely why I quit Zoloft on 3 occasions! First time in 2008. Could not past the 3rd day. Very tired, minor tremors. Second time I tried was last month. Only I started at 25mg instead of 50 as the doc prescribed. That was easier for me. I stayed on 25 for 2 weeks, stopped agin after 3 days, but went back on it, by the 2nd week all the side effects vanished while I was getting use to 25mg. Then I went up to 50mg with no noticeable difference and no side effects. Stayed on 50 for 7 days, then went to full tab 100mg, for past 5 days. I did feel some side effects but nothing to serious. I'm also taking Wellbutrin too.

Zoloft does take some getting use to be yes the side effects go away, but I think docs push us too quickly on it and that's why so many stopped before the 2nd week!